Technology Innovation for Drug Discovery

Our researchers have rich experience in organic synthesis, especially in syntheses of unnatural amino acids, enzyme resolution of amino acids, syntheses of azetidine derivatives etc. The advent of novel polypeptide drug and some pharmaceutical units with various amino acids has acted as a stimulant for continuous and further demanding of novel amino acids. The heterocyclic compounds have attracted much attention because of their special bioactivities. Based on this reason, our chemists focused on research & development for amino acid and novel heterocycles.

Take advantage of our Contract Services to produce various analogs and substitutions of building blocks necessary to your drug discovery and medicinal chemistry work.

• Reaction Capabilities
• Suzuki Coupling
• Sonogashira Reaction
• Stille Cross-Coupling
• Heck Reaction
• Enzyme Resolution
• Chiral Catalysis
• Baeyer-Villiger Reaction
• Bromination
• Chlorination
• Cyanation
• Diazotization
• Catalytic hydrogenation
• Alkylation
• Nitration
• Formylation
• Mannich reaction
• Reduction
• Oxidation
• Vilsmeier reaction
• Wittig reaction
• Buchwald Reaction
• Etherification
• Ring Closure
• Ullwann Reaction

References:

1. Littke, A. F.; Dai, C.; Fu, G. C. J. Am. Chem. Soc. 2000, 122, 4020.
2. Hundertmark, T.; Littke, A. F.; Buchwald, S. L.; Fu, G. C. Org. Lett. 2000, 2, 1729.
3. Soheili, A.; Albaneze-Walker, J.; Murry, J. A.; Dormer, P. G.; Hughes, D. L. Org. Lett. 2003, 5, 4191.
4. Holz, J.; Monsees, A.; Jiao, H.; You, J.; Komarov, I. V.; Fischer, C.; Drauz, K.; Borner, A. J. Org. Chem. 2003, 68, 1701
5. D. Zim, S. L. Buchwald, Org. Lett., 2003, 5, 2413-2415

Main Facilities:

• Reaction Vessels (Glass-lined): 50-500 liters
• Reaction Vessels (Glass-lined): 500-2000 liters
• Reaction Vessels (Stainless Steel): 300-1000 liters
• Centrifuge (Stainless Steel)
• Refrigerating Machine: 105,000 Kcal
• GC, HPLC, LC-MS
• Bruker 300M NMR